The shifting landscape of regulatory frameworks, national policies and global markets for food and agriculture have significant implications for food security and rural development, especially given the projected impact of climate change on supply and demand patterns in years ahead. These evolving trends create new challenges for government delegates as they seek to determine what negotiating outcomes might be possible, desirable and necessary at the WTO's tenth ministerial conference in Nairobi and beyond. In particular, the conclusion in early October of a major preferential trade agreement by twelve WTO members in the Pacific region is likely to alter the dynamics of multilateral trade negotiations, by establishing new market access arrangements and establishing new norms among a significant sub-set of the WTO membership. At the same time, political considerations in some of the world's major trading powers appears to shape what can be achieved both at Nairobi and in the period following the ministerial conference. This meeting explored how domestic political constraints relate to the negotiating context at the international level, and how these considerations inform possible outcomes for Nairobi and beyond. It also examined the priorities for low-income, food insecure countries in this emerging environment.